Liver Lore

Fatty liver disease (NAFLD/MASLD): complete guide

“Fatty liver” is one of the most common findings on Indian health check-up reports, and one of the most ignored. Most of the time it is a warning, not a crisis. Here is what it means, why the name changed to MASLD, how doctors check whether it is serious, and what actually helps.

Written by Hesha Kagrana, PhysiotherapistLast updated 6 minute read

Key points

  • Fatty liver means extra fat stored in the liver. When it is linked to weight, blood sugar, blood pressure or cholesterol, it is now called MASLD (formerly NAFLD).
  • Indian studies suggest it affects nearly 4 in 10 adults, including many who are not overweight.
  • Most people have no symptoms. The key question is not the fat itself but whether scarring (fibrosis) is developing, which simple tests such as FIB-4 and FibroScan can check.
  • Lifestyle change is the main treatment, and it works: losing 7 to 10% of body weight can reverse much of the fat and inflammation.

A typical story: a 38-year-old IT professional goes for the annual office health check-up. Everything looks fine except one line on the ultrasound: “Grade 1 fatty liver”. The doctor says “eat less oil, walk more”, and that is the end of it. Sometimes that is the right advice. But fatty liver is also the most common liver disease in India and an early sign of metabolic problems, so it is worth understanding properly.

What fatty liver is

A healthy liver contains a little fat. When fat makes up more than about 5% of the liver, doctors call it fatty liver, or steatosis. On its own, fat in the liver usually causes no harm. In some people, though, it triggers inflammation that slowly scars the liver over years. That scarring, called fibrosis, is what decides the long-term risk.

NAFLD, MASLD and MASH: what the names mean

In 2023, international liver societies agreed new names, because the old ones were defined by what the condition was not (“non-alcoholic”) and some patients found “fatty” stigmatising:

Old nameNew nameWhat it means
NAFLD (non-alcoholic fatty liver disease)MASLD: metabolic dysfunction-associated steatotic liver diseaseFatty liver plus at least one metabolic factor, such as excess weight or waist, high blood sugar, high blood pressure or abnormal cholesterol
NASH (non-alcoholic steatohepatitis)MASH: metabolic dysfunction-associated steatohepatitisFatty liver with inflammation and liver cell damage
(new)MetALDMetabolic fatty liver in someone who also drinks a moderate amount of alcohol

Most people who had NAFLD now have MASLD, and the research on NAFLD still applies. Your report may still say “fatty liver” with a grade; our guide to fatty liver grades on ultrasound explains what those grades do and do not tell you.

How common it is in India

A review of Indian studies estimated that about 38.6% of adults have fatty liver, and about a third of children in the studies examined. It is more common in cities and in people with diabetes or obesity, but India also has many people with “lean” fatty liver: a normal BMI but extra fat around the waist and in the liver, often alongside insulin resistance.

Causes and risk factors

  • Extra weight, especially around the waist
  • Type 2 diabetes or prediabetes
  • High triglycerides or low HDL cholesterol
  • High blood pressure
  • Diets high in refined carbohydrates, sugar, sugary drinks and fried food
  • Sitting most of the day
  • PCOS, underactive thyroid, sleep apnoea
  • Family history and genes

Other causes of fat in the liver, such as heavy alcohol use, hepatitis C, some medicines and rapid weight loss, need to be ruled out, because they are managed differently.

Symptoms of fatty liver

Most people with fatty liver feel completely normal. When symptoms do appear, they are usually vague: tiredness, or a dull ache or heaviness in the upper right part of the tummy. Signs of advanced disease, such as yellow eyes, a swollen tummy, swelling of the legs, easy bruising, vomiting blood or confusion, usually mean scarring has already progressed to cirrhosis and need prompt medical attention. Our guide to fibrosis and cirrhosis covers this.

How it is diagnosed

  • Ultrasound is how most people in India find out. It shows fat when there is a moderate amount, but cannot measure scarring.
  • Liver function tests (SGPT/ALT, SGOT/AST and others) may be normal or mildly raised. Normal results do not rule out fatty liver or fibrosis. See liver function tests explained.
  • FIB-4 score, calculated from your age, SGOT, SGPT and platelet count, is the recommended first check for scarring.
  • FibroScan (transient elastography) measures liver stiffness, which reflects scarring, and is widely available in Indian cities.
  • Tests for other causes: hepatitis B and C, alcohol history, medicines, and sometimes others.
  • Metabolic checks: blood sugar or HbA1c, cholesterol and blood pressure, because heart disease is the leading cause of death in people with fatty liver.

When fatty liver is serious

The AASLD and European guidelines use a simple step-by-step approach. If the FIB-4 is low, the risk of significant scarring is low, and the focus is lifestyle and heart health, with re-checks every few years. If FIB-4 is intermediate or high, a FibroScan or similar test comes next. People with signs of significant fibrosis should see a liver specialist (hepatologist or gastroenterologist).

Treatment

Lifestyle is the main treatment, and it works. The AASLD guidance notes that losing 3 to 5% of body weight reduces liver fat, 7% or more improves inflammation, and 10% or more can improve scarring. Exercise helps even without weight loss. Our guide to diet and exercise for fatty liver shows how to do this with Indian food and daily routines.

  • Alcohol: best kept to a minimum, and avoided completely if there is significant fibrosis.
  • Diabetes, blood pressure and cholesterol: treating these protects both the heart and the liver. Some diabetes and weight-loss medicines also benefit the liver, and statins are safe in fatty liver.
  • Medicines for the liver itself: a few have been approved in some countries for people with MASH and significant fibrosis. They are prescribed by specialists and are not needed by most people with fatty liver.
  • “Liver detox” products and herbal tonics: there is no evidence they treat fatty liver, and Indian liver specialists have reported liver injury linked to some herbal and dietary supplements. Tell your doctor about everything you take.
  • Vaccination against hepatitis A and B is often recommended for people with chronic liver disease.

When to see a doctor

  • Your report shows fatty liver and you have not had your sugar, cholesterol and FIB-4 checked.
  • Your FIB-4 or FibroScan result suggests scarring.
  • Your SGPT or SGOT stays raised for months.
  • Yellow eyes or skin, a swollen tummy, swelling of the legs, or easy bruising.
  • Vomiting blood, black stools or confusion: call 112.

Questions to ask your doctor

  • Is my fatty liver due to metabolic factors, alcohol, or something else?
  • What is my FIB-4 score, and do I need a FibroScan?
  • What weight loss target is realistic for me?
  • How often should my liver be re-checked?

Frequently asked questions

Is fatty liver dangerous?

Fat in the liver alone is usually not dangerous, but it is a warning sign. In some people it leads to inflammation and scarring over years, and it is linked to diabetes and heart disease. A FIB-4 score or FibroScan shows whether scarring is developing.

Can fatty liver be reversed?

Yes, in most people. Losing 3 to 5% of body weight reduces liver fat, and 7 to 10% or more can reduce inflammation and even scarring. Regular exercise helps even without weight loss.

What is the difference between NAFLD and MASLD?

MASLD is the new name for most cases of NAFLD, agreed in 2023. It means fatty liver linked to at least one metabolic factor, such as excess weight, high blood sugar, high blood pressure or abnormal cholesterol.

Can thin people get fatty liver?

Yes. Many Indians with a normal BMI have fatty liver, often with extra fat around the waist and insulin resistance. This is sometimes called lean fatty liver, and it needs the same checks.

What are the symptoms of fatty liver?

Most people have no symptoms. Some notice tiredness or a dull ache in the upper right tummy. Yellow eyes, a swollen tummy or leg swelling suggest advanced disease and need prompt medical care.

Sources

  1. Rinella ME, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol 2023;79(6):1542–1556.
  2. Rinella ME, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology 2023;77(5):1797–1835.
  3. European Association for the Study of the Liver, et al. EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol 2024;81(3):492–542.
  4. Shalimar, et al. Prevalence of non-alcoholic fatty liver disease in India: a systematic review and meta-analysis. J Clin Exp Hepatol 2022.

This article is general information for adults in India and is not a diagnosis or a treatment plan. Always discuss results and any changes with your own doctor. Read our editorial policy.